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藥物靶點重組兔單克隆抗體
締碼生物創(chuàng)新性的兔重組單克隆抗體平臺，聚焦腫瘤免疫靶點，使用功能活性充分驗證的重組蛋白作為抗原免疫兔子，直接從陽性兔B細(xì)胞中克隆IgG，重組表達(dá)進(jìn)行流式驗證。這一技術(shù)不僅大大縮短了研發(fā)的時間，也讓我們能夠直接獲得IgG的基因序列信息，而無需擔(dān)心雜交瘤細(xì)胞丟失。
DIMA mAbs優(yōu)勢
現(xiàn)貨供應(yīng)，覆蓋多個熱門腫瘤靶點：
已成功開發(fā)出5000+兔單抗產(chǎn)品，覆蓋500余種靶點。
應(yīng)用范圍廣泛：
產(chǎn)品均經(jīng)過ELISA或流式驗證，還可開發(fā)WB、IHC、IF、熒光標(biāo)記等應(yīng)用。
高特異性、高親和力：
兔抗體基因庫具有更高多樣性，更高親和力，表位覆蓋更廣。
多種抗體類型：
兔單抗、人兔嵌合抗體、人源化抗體等。
成藥性高：
締碼基于單B細(xì)胞技術(shù)的兔單抗發(fā)現(xiàn)平臺開發(fā)出來的抗體成藥性高。
高性價比，定制靈活：
可提供多標(biāo)簽、多種屬及大規(guī)格包裝定制。
B細(xì)胞種子庫高效篩選兔單抗
締碼生物擁有獨創(chuàng)的DIMA mAbs重組單克隆抗體開發(fā)平臺，可以在完成動物免疫后直接從外周血中獲取陽性B細(xì)胞并克隆抗體基因序列。從單只免疫動物中我們可以得到上萬個靶點結(jié)合陽性B細(xì)胞克隆，從中能夠更為高效的篩選出具有高特異性、高親和力重組單克隆抗體。
熱門抗體靶點
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
驗證數(shù)據(jù)展示
A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.
Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.
Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10μg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10μg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)
A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.?
單克隆抗體
Monoclonal Antibodies
SKU: DME101203 Target: PF4V1
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101202 Target: TAFA5
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101201 Target: AGR2
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101404 Target: SIGLEC9
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101403 Target: IL12RB1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101218 Target: CD9
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101217 Target: CEACAM1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101189 Target: A35R
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101188 Target: LGR4
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101380 Target: ACVRL1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101187 Target: A29L
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101186 Target: GAST
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101185 Target: LAIR1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101184 Target: IL19
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101183 Target: GPR56
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101379 Target: CD14
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101182 Target: CXCL10
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101378 Target: AREG
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101181 Target: LGALS3
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101180 Target: IFNB1
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101179 Target: RSPO3
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101063 Target: G4S linker
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101144P Target: G4S linker
Application: Flow Cyt
100 test ￥3880.00
Monoclonal Antibodies
SKU: DME101139 Target: Rabbit IgG
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101138 Target: Rabbit IgG
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101360 Target: IL21
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101359 Target: GAS6
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101358 Target: SPARC
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101357 Target: ACVR2A
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101356 Target: MET
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101354 Target: IL13
Application: ELISA
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101144 Target: G4S linker
Application: ELISA FC
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
