藥物靶點(diǎn)重組兔單克隆抗體

締碼生物創(chuàng)新性的兔重組單克隆抗體平臺，聚焦腫瘤免疫靶點(diǎn)，使用功能活性充分驗(yàn)證的重組蛋白作為抗原免疫兔子，直接從陽性兔B細(xì)胞中克隆IgG，重組表達(dá)進(jìn)行流式驗(yàn)證。這一技術(shù)不僅大大縮短了研發(fā)的時間，也讓我們能夠直接獲得IgG的基因序列信息，而無需擔(dān)心雜交瘤細(xì)胞丟失。

DIMA mAbs優(yōu)勢

現(xiàn)貨供應(yīng)，覆蓋多個熱門腫瘤靶點(diǎn)：

已成功開發(fā)出5000+兔單抗產(chǎn)品，覆蓋500余種靶點(diǎn)。

應(yīng)用范圍廣泛：

產(chǎn)品均經(jīng)過ELISA或流式驗(yàn)證，還可開發(fā)WB、IHC、IF、熒光標(biāo)記等應(yīng)用。

高特異性、高親和力：

兔抗體基因庫具有更高多樣性，更高親和力，表位覆蓋更廣。

多種抗體類型：

兔單抗、人兔嵌合抗體、人源化抗體等。

成藥性高：

締碼基于單B細(xì)胞技術(shù)的兔單抗發(fā)現(xiàn)平臺開發(fā)出來的抗體成藥性高。

高性價比，定制靈活：

可提供多標(biāo)簽、多種屬及大規(guī)格包裝定制。

B細(xì)胞種子庫高效篩選兔單抗

締碼生物擁有獨(dú)創(chuàng)的DIMA mAbs重組單克隆抗體開發(fā)平臺，可以在完成動物免疫后直接從外周血中獲取陽性B細(xì)胞并克隆抗體基因序列。從單只免疫動物中我們可以得到上萬個靶點(diǎn)結(jié)合陽性B細(xì)胞克隆，從中能夠更為高效的篩選出具有高特異性、高親和力重組單克隆抗體。

驗(yàn)證數(shù)據(jù)展示

A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.

Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.

Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10μg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10μg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)

A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.?

Affinity ranking of different Rabbit anti-CS1 mAb clones (DM9, DM10, DM11) by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

單克隆抗體

Monoclonal Antibodies

PE-conjugated Anti-GPR75 antibody(DMC368); IgG1 Chimeric mAb

SKU: DMC100368P Target: GPR75

Application: Flow Cyt

Price: 100 test ￥3880.00

Monoclonal Antibodies

PE-conjugated Anti-CD30 Ligand antibody(DM201); Rabbit mAb

SKU: DME100201P Target: CD30 Ligand

Application: Flow Cyt

Price: 100 test ￥3880.00

Monoclonal Antibodies

Biotinylated Anti-GPR75 antibody(12B6), Rabbit mAb

SKU: DME101136B Target: GPR75

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Anti-GPR75 antibody(12B6), Rabbit mAb

SKU: DME101136 Target: GPR75

Application: Flow Cyt