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藥物靶點重組兔單克隆抗體
締碼生物創(chuàng)新性的兔重組單克隆抗體平臺，聚焦腫瘤免疫靶點，使用功能活性充分驗證的重組蛋白作為抗原免疫兔子，直接從陽性兔B細胞中克隆IgG，重組表達進行流式驗證。這一技術不僅大大縮短了研發(fā)的時間，也讓我們能夠直接獲得IgG的基因序列信息，而無需擔心雜交瘤細胞丟失。
DIMA mAbs優(yōu)勢
現(xiàn)貨供應，覆蓋多個熱門腫瘤靶點：
已成功開發(fā)出5000+兔單抗產(chǎn)品，覆蓋500余種靶點。
應用范圍廣泛：
產(chǎn)品均經(jīng)過ELISA或流式驗證，還可開發(fā)WB、IHC、IF、熒光標記等應用。
高特異性、高親和力：
兔抗體基因庫具有更高多樣性，更高親和力，表位覆蓋更廣。
多種抗體類型：
兔單抗、人兔嵌合抗體、人源化抗體等。
成藥性高：
締碼基于單B細胞技術的兔單抗發(fā)現(xiàn)平臺開發(fā)出來的抗體成藥性高。
高性價比，定制靈活：
可提供多標簽、多種屬及大規(guī)格包裝定制。
B細胞種子庫高效篩選兔單抗
締碼生物擁有獨創(chuàng)的DIMA mAbs重組單克隆抗體開發(fā)平臺，可以在完成動物免疫后直接從外周血中獲取陽性B細胞并克隆抗體基因序列。從單只免疫動物中我們可以得到上萬個靶點結合陽性B細胞克隆，從中能夠更為高效的篩選出具有高特異性、高親和力重組單克隆抗體。
熱門抗體靶點
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
驗證數(shù)據(jù)展示
A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.
Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.
Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10μg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10μg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)
A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.?
單克隆抗體
Monoclonal Antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM38); Rabbit mAb
SKU: DME100037B Target: Nucleocapsid
Application: ELISA
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM37); Rabbit mAb
SKU: DME100036B Target: Nucleocapsid
Application: ELISA
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM36); Rabbit mAb
SKU: DME100035B Target: Nucleocapsid
Application: ELISA
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100034B Target: S protein RBD
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100026B Target: S protein RBD
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100025B Target: S protein RBD
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-SARS-CoV-2 Spike antibody(DM25); Rabbit mAb
SKU: DME100018B Target: S protein
Application: ELISA
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-SARS-CoV-2 Spike antibody(DM24); Rabbit mAb
SKU: DME100017B Target: S protein
Application: ELISA
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM23); Rabbit mAb
SKU: DME100016B Target: Nucleocapsid
Application: ELISA
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-SARS-CoV-2 Nucleocapsid antibody(DM22); Rabbit mAb
SKU: DME100015B Target: Nucleocapsid
Application: ELISA
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100001B Target: His Tag
Application: ELISA; WB
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME201008 Target: DDK
Application: ELISA, WB
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME100014B Target: CD22
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100013B Target: CD22
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100012B Target: CD22
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100011B Target: CS1
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100008B Target: SIRPa
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100082B Target: TIM3
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100078B Target: GITR
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100076B Target: Trop2
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100075B Target: Trop2
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100074B Target: Trop2
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100073B Target: MSLN
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100072B Target: MSLN
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100071B Target: MSLN
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100068B Target: 4-1BB Ligand
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100063B Target: CD28
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100052B Target: GITR Ligand
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100050B Target: CTLA-4
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100049B Target: CTLA-4
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100048B Target: CD47
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DME100047B Target: ACE2
Application: ELISA; Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
