基因過(guò)表達(dá)穩(wěn)轉(zhuǎn)細(xì)胞株

締碼提供針對(duì)不同靶點(diǎn)的100+基因過(guò)表達(dá)細(xì)胞株產(chǎn)品,源自K562, 293T, CHO, Jurkat等細(xì)胞。我們專(zhuān)注于為客戶(hù)提供卓越的解決方案,我們的細(xì)胞株已被證明在先導(dǎo)抗體臨床前驗(yàn)證中是有效的。憑借我們現(xiàn)成的細(xì)胞株和可定制的生產(chǎn)服務(wù),我們保證滿(mǎn)足您的研究需求,無(wú)論是在早期抗體驗(yàn)證還是其他領(lǐng)域,都將推動(dòng)您取得成功。

產(chǎn)品

Catalog NumberTargetHost CellsProduct Name
CEL100001GPRC5DK562Hu_GPRC5D K562 Cell Line
CEL100002BCMAK562Hu_BCMA K562 Cell Line
CEL1000035T4K562Hu_5T4 K562 Cell Line
CEL100004FAPK562Hu_FAP K562 Cell Line
CEL100005EGFRK562Hu_EGFR K562 Cell Line
CEL100006CD48K562Hu_CD48 K562 Cell Line
CEL100007CD70K562Hu_CD70 K562 Cell Line
CEL100008MesothelinK562Hu_MSLN K562 Cell Line
CEL100009CDH17K562Hu_CDH17 K562 Cell Line
CEL100010SSTR2K562Hu_SSTR2 K562 Cell Line
CEL100018CD20K562Hu_CD20 K562 Cell Line
CEL100019PSMAK562Hu_PSMA K562 Cell Line
CEL100021EGFR VIIIK562Hu_EGFR VIII K562 Cell Line
CEL100022PD-L1K562Hu_PD-L1 K562 Cell Line
CEL100023PD-L1JurkatHu_PD-L1 Jurkat Cell Line
CEL100024FOLR1293THu_FOLR1 293T Cell Line
CEL100025CD33293THu_CD33 293T Cell Line
CEL100026CD30293THu_CD30 293T Cell Line
CEL100027MUC1293THu_MUC1 293T Cell Line
CEL100028EPCAMJurkatHu_EPCAM Jurkat Cell Line
CEL100029Nectin-4K562Hu_Nectin-4 K562 Cell Line
CEL100030Trop2K562Hu_TROP2 K562 Cell Line
CEL100031TIM3K562Hu_TIM3 K562 Cell Line
CEL100032HER3JurkatHu_HER3 Jurkat Cell Line
CEL100034VISTA293THu_VISTA 293T Cell Line
CEL100036CD37293THu_CD37 293T Cell Line
CEL100037SEZ6K562Hu_SEZ6 K562 Cell Line
CEL100038DLL3CHO-SHu_DLL3 CHO-S Cell Line
CEL100039DLL3293THu_DLL3 293T Cell Line
CEL100040CD47CHO-SHu_CD47 CHO-S Cell Line
CEL100041CD28K562Hu_CD28 K562 Cell Line
CEL100042B7H4K562Hu_B7H4 K562 Cell Line
CEL100043CD46CHO-SHu_CD46 CHO-S Cell Line
CEL100044ROR2CHO-SHu_ROR2 CHO-S Cell Line
CEL100045CA9CHO-SHu_CA9 CHO-S Cell Line
CEL100046MICACHO-SHu_MICA CHO-S Cell Line
CEL100047MICBCHO-SHu_MICB CHO-S Cell Line
CEL100048CD44CHO-SHu_CD44 CHO-S Cell Line
CEL100049CD142K562Hu_CD142 K562 Cell Line
CEL100050TGFBR2K562Hu_TGFBR2 K562 Cell Line
CEL100052CD74CHO-SHu_CD74 CHO-S Cell Line
CEL100053FZD10K562Hu_FZD10 K562 Cell Line
CEL100055CDH6CHO-SHu_CDH6 CHO-S Cell Line
CEL100056ENPP3CHO-SHu_ENPP3 CHO-S Cell Line
CEL100057CD166K562Hu_CD166 K562 Cell Line
CEL100058CEACAM6K562Hu_CEACAM6 K562 Cell Line
CEL100060CDH3CHO-SHu_CDH3 CHO-S Cell Line
CEL100061GPNMBCHO-SHu_GPNMB CHO-S Cell Line
CEL100062TIM1K562Hu_TIM1 K562 Cell Line
CEL100063NTB-ACHO-SHu_NTB-A CHO-S Cell Line
CEL100064TNFRSF10BCHO-SHu_TNFRSF10B CHO-S Cell Line
CEL100065CLDN6K562Hu_CLDN6 K562 Cell Line
CEL100066CLDN6CHO-SHu_CLDN6 CHO-S Cell Line
CEL100067CLDN6293THu_CLDN6 293T Cell Line
CEL100068IGF1RCHO-SHu_IGF1R CHO-S Cell Line
CEL100069TFRCCHO-SHu_TFRC CHO-S Cell Line
CEL100070CLEC12AK562Hu_CLEC12A K562 Cell Line
CEL100071HVEMCHO-SHu_HVEM CHO-S Cell Line
CEL100072CD10CHO-SHu_CD10 CHO-S Cell Line
CEL100073CD114JurkatHu_CD114 Jurkat Cell Line
CEL100074VEGFR2K562Hu_VEGFR2 K562 Cell Line
CEL100075CCR4CHO-SHu_CCR4 CHO-S Cell Line
CEL100076AMHR2JurkatHu_AMHR2 Jurkat Cell Line
CEL100077CD112CHO-SHu_CD112 CHO-S Cell Line
CEL100078CD52CHO-SHu_CD52 CHO-S Cell Line
CEL100079CD79BCHO-SHu_CD79B CHO-S Cell Line
CEL100080ICOSK562Hu_ICOS K562 Cell Line
CEL100081CD27CHO-SHu_CD27 CHO-S Cell Line
CEL100082CD63CHO-SHu_CD63 CHO-S Cell Line
CEL100083TIGITK562Hu_TIGIT K562 Cell Line
CEL100084GPC3K562Hu_GPC3 K562 Cell Line
CEL100086IL21RK562Hu_IL21R K562 Cell Line
CEL100087VSIG4JurkatHu_VSIG4 Jurkat Cell Line
CEL100088CCR2K562Hu_CCR2 K562 Cell Line
CEL100089CDH1CHO-SHu_CDH1 CHO-S Cell Line
CEL100090CCR5K562Hu_CCR5 K562 Cell Line
CEL100091BTLAK562Hu_BTLA K562 Cell Line
CEL100092GPR75CHO-SHu_GPR75 CHO-S Cell Line

服務(wù)

締碼根據(jù)您的需求提供定制的穩(wěn)轉(zhuǎn)細(xì)胞株服務(wù)。我們經(jīng)驗(yàn)豐富的團(tuán)隊(duì)利用尖端技術(shù),以高效率和可靠性制備穩(wěn)定的細(xì)胞株,表達(dá)您感興趣的基因。從構(gòu)建到穩(wěn)定的細(xì)胞單克隆選擇和基因表達(dá)評(píng)估,以簡(jiǎn)化并加速您的研究過(guò)程。

  • 服務(wù)內(nèi)容包括

1.構(gòu)建:將您感興趣的基因構(gòu)建到慢病毒載體中,生產(chǎn)較高滴度的慢病毒進(jìn)行轉(zhuǎn)導(dǎo)。

2. 穩(wěn)定細(xì)胞單克隆選擇:轉(zhuǎn)導(dǎo)后選擇以獲得穩(wěn)定的細(xì)胞單克隆。

3. 驗(yàn)證:使用各種測(cè)定法評(píng)估穩(wěn)定細(xì)胞單克隆中的基因表達(dá)。

案例展示

GPRC5D已成為癌癥和免疫學(xué)研究的焦點(diǎn),引起了業(yè)界的極大興趣。締碼能夠提供必要的工具來(lái)探索其潛力,包括功能蛋白和特異性抗體。為了便于臨床試驗(yàn)前的初步篩選,我們開(kāi)發(fā)了過(guò)表達(dá)GPRC5D的穩(wěn)轉(zhuǎn)細(xì)胞株。這些細(xì)胞系作為評(píng)估候選抗體的重要工具,進(jìn)一步簡(jiǎn)化了臨床研究的篩選過(guò)程,旨在幫助生物制藥公司加快抗體藥臨床前開(kāi)發(fā)的步伐。

fc-cel100001 h gprc5d k562 cell line flow

G00 (The red arrow is the construct from reference CAR (MARCH109, which is in clinical trial); G01-G09 are humanized molecules from DlMA Biotech LTD.

Cytotoxicity screening of ADC candidate antibodies using the 293T-DLL3 stable cell line(Cat. No.CEL100039) helps identify antibodies with effective internalization.

Using K562 stable cell lines expressing GPRC5D/BCMA as surrogate tumor cells, co-cultured with CAR-T cells. In this 7-day assay, CAR-T cells undergo four rounds of tumor challenge to assess the cytotoxicity of T cells against these “target cells,” thereby evaluating the specificity of T cell-mediated killing and the potential off-target risks.

優(yōu)勢(shì)

靶點(diǎn)多樣性

從我們多樣化的穩(wěn)轉(zhuǎn)細(xì)胞株中選擇表達(dá)與藥物開(kāi)發(fā)相關(guān)的靶點(diǎn)

質(zhì)量可靠性

我們的穩(wěn)轉(zhuǎn)細(xì)胞株經(jīng)過(guò)嚴(yán)格的質(zhì)量控制措施,以確保一致性和可重復(fù)性。

服務(wù)定制化

我們會(huì)根據(jù)您的具體研究要求設(shè)計(jì)定制的穩(wěn)轉(zhuǎn)細(xì)胞株。

其他產(chǎn)品