藥物靶點(diǎn)重組兔單克隆抗體

締碼生物創(chuàng)新性的兔重組單克隆抗體平臺(tái)，聚焦腫瘤免疫靶點(diǎn)，使用功能活性充分驗(yàn)證的重組蛋白作為抗原免疫兔子，直接從陽(yáng)性兔B細(xì)胞中克隆IgG，重組表達(dá)進(jìn)行流式驗(yàn)證。這一技術(shù)不僅大大縮短了研發(fā)的時(shí)間，也讓我們能夠直接獲得IgG的基因序列信息，而無(wú)需擔(dān)心雜交瘤細(xì)胞丟失。

DIMA mAbs優(yōu)勢(shì)

現(xiàn)貨供應(yīng)，覆蓋多個(gè)熱門(mén)腫瘤靶點(diǎn)：

已成功開(kāi)發(fā)出5000+兔單抗產(chǎn)品，覆蓋500余種靶點(diǎn)。

應(yīng)用范圍廣泛：

產(chǎn)品均經(jīng)過(guò)ELISA或流式驗(yàn)證，還可開(kāi)發(fā)WB、IHC、IF、熒光標(biāo)記等應(yīng)用。

高特異性、高親和力：

兔抗體基因庫(kù)具有更高多樣性，更高親和力，表位覆蓋更廣。

多種抗體類型：

兔單抗、人兔嵌合抗體、人源化抗體等。

成藥性高：

締碼基于單B細(xì)胞技術(shù)的兔單抗發(fā)現(xiàn)平臺(tái)開(kāi)發(fā)出來(lái)的抗體成藥性高。

高性價(jià)比，定制靈活：

可提供多標(biāo)簽、多種屬及大規(guī)格包裝定制。

B細(xì)胞種子庫(kù)高效篩選兔單抗

締碼生物擁有獨(dú)創(chuàng)的DIMA mAbs重組單克隆抗體開(kāi)發(fā)平臺(tái)，可以在完成動(dòng)物免疫后直接從外周血中獲取陽(yáng)性B細(xì)胞并克隆抗體基因序列。從單只免疫動(dòng)物中我們可以得到上萬(wàn)個(gè)靶點(diǎn)結(jié)合陽(yáng)性B細(xì)胞克隆，從中能夠更為高效的篩選出具有高特異性、高親和力重組單克隆抗體。

熱門(mén)抗體靶點(diǎn)

2B44-1BB4-1BB-LSIRPα
B7-H3BCMACD123CD48
CD138CD22CD27GITR Ligand
CD28CD38CD47CS1
GPRC5DCTLA-4MSLNTROP2
GITRTIM3B7-2PSCA
NKp30BTN3A1DNAM1B7-H2
CD40

驗(yàn)證數(shù)據(jù)展示

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A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.

Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.

Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10μg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10μg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)

A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.?

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Affinity ranking of different Rabbit anti-CS1 mAb clones (DM9, DM10, DM11) by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

單克隆抗體

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