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藥物靶點重組兔單克隆抗體
締碼生物創(chuàng)新性的兔重組單克隆抗體平臺，聚焦腫瘤免疫靶點，使用功能活性充分驗證的重組蛋白作為抗原免疫兔子，直接從陽性兔B細(xì)胞中克隆IgG，重組表達(dá)進(jìn)行流式驗證。這一技術(shù)不僅大大縮短了研發(fā)的時間，也讓我們能夠直接獲得IgG的基因序列信息，而無需擔(dān)心雜交瘤細(xì)胞丟失。
DIMA mAbs優(yōu)勢
現(xiàn)貨供應(yīng)，覆蓋多個熱門腫瘤靶點：
已成功開發(fā)出5000+兔單抗產(chǎn)品，覆蓋500余種靶點。
應(yīng)用范圍廣泛：
產(chǎn)品均經(jīng)過ELISA或流式驗證，還可開發(fā)WB、IHC、IF、熒光標(biāo)記等應(yīng)用。
高特異性、高親和力：
兔抗體基因庫具有更高多樣性，更高親和力，表位覆蓋更廣。
多種抗體類型：
兔單抗、人兔嵌合抗體、人源化抗體等。
成藥性高：
締碼基于單B細(xì)胞技術(shù)的兔單抗發(fā)現(xiàn)平臺開發(fā)出來的抗體成藥性高。
高性價比，定制靈活：
可提供多標(biāo)簽、多種屬及大規(guī)格包裝定制。
B細(xì)胞種子庫高效篩選兔單抗
締碼生物擁有獨創(chuàng)的DIMA mAbs重組單克隆抗體開發(fā)平臺，可以在完成動物免疫后直接從外周血中獲取陽性B細(xì)胞并克隆抗體基因序列。從單只免疫動物中我們可以得到上萬個靶點結(jié)合陽性B細(xì)胞克隆，從中能夠更為高效的篩選出具有高特異性、高親和力重組單克隆抗體。
熱門抗體靶點
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
驗證數(shù)據(jù)展示
A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.
Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.
Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10μg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10μg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)
A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.?
單克隆抗體
Monoclonal Antibodies
SKU: DMC100388P Target: EDA
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-ADGRE2 antibody(DMC370); IgG1 Chimeric mAb
SKU: DMC100370P Target: ADGRE2
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100366P Target: CFB
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-SLAMF5 antibody(DMC286); IgG1 Chimeric mAb
SKU: DMC100286P Target: SLAMF5
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100285P Target: CD96
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CD162 antibody(DMC283); IgG1 Chimeric mAb
SKU: DMC100283P Target: SELPLG
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-IL11RA antibody(DMC282); IgG1 Chimeric mAb
SKU: DMC100282P Target: IL11RA
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100281P Target: AFP
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100280P Target: CD21
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-Galectin 9 antibody(DMC279); IgG1 Chimeric mAb
SKU: DMC100279P Target: Galectin 9
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-JAM-A antibody(DMC278); IgG1 Chimeric mAb
SKU: DMC100278P Target: JAM-A
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-LGALS1 antibody(DMC277); IgG1 Chimeric mAb
SKU: DMC100277P Target: LGALS1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-VEGFA antibody(DMC276); IgG1 Chimeric mAb
SKU: DMC100276P Target: VEGFA
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100275P Target: ALB
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100274P Target: IL5
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100273P Target: CD36
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CD160 antibody(DMC270); IgG1 Chimeric mAb
SKU: DMC100270P Target: CD160
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100269P Target: CD44
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-VSIG4 antibody(DMC268); IgG1 Chimeric mAb
SKU: DMC100268P Target: VSIG4
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100008P Target: SIRPa
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-IL21R antibody(DMC225); IgG1 Chimeric mAb
SKU: DMC100225P Target: IL21R
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CD112 antibody(DMC224); IgG1 Chimeric mAb
SKU: DMC100224P Target: CD112
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-TREM2 antibody(DMC223); IgG1 Chimeric mAb
SKU: DMC100223P Target: TREM2
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-FCGR3A antibody(DMC219); IgG1 Chimeric mAb
SKU: DMC100219P Target: FCGR3A
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100218P Target: IL18RA
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100211P Target: CD43
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100209P Target: NRG1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100208P Target: CXCR3
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100206P Target: IL15RA
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100205P Target: ANGPTL3
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100203P Target: CD99
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DME100194P Target: SCF
Application: Flow Cyt
Price: 100 test ￥3880.00
