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藥物靶點(diǎn)重組兔單克隆抗體
締碼生物創(chuàng)新性的兔重組單克隆抗體平臺(tái)，聚焦腫瘤免疫靶點(diǎn)，使用功能活性充分驗(yàn)證的重組蛋白作為抗原免疫兔子，直接從陽性兔B細(xì)胞中克隆IgG，重組表達(dá)進(jìn)行流式驗(yàn)證。這一技術(shù)不僅大大縮短了研發(fā)的時(shí)間，也讓我們能夠直接獲得IgG的基因序列信息，而無需擔(dān)心雜交瘤細(xì)胞丟失。
DIMA mAbs優(yōu)勢
現(xiàn)貨供應(yīng)，覆蓋多個(gè)熱門腫瘤靶點(diǎn)：
已成功開發(fā)出5000+兔單抗產(chǎn)品，覆蓋500余種靶點(diǎn)。
應(yīng)用范圍廣泛：
產(chǎn)品均經(jīng)過ELISA或流式驗(yàn)證，還可開發(fā)WB、IHC、IF、熒光標(biāo)記等應(yīng)用。
高特異性、高親和力：
兔抗體基因庫具有更高多樣性，更高親和力，表位覆蓋更廣。
多種抗體類型：
兔單抗、人兔嵌合抗體、人源化抗體等。
成藥性高：
締碼基于單B細(xì)胞技術(shù)的兔單抗發(fā)現(xiàn)平臺(tái)開發(fā)出來的抗體成藥性高。
高性價(jià)比，定制靈活：
可提供多標(biāo)簽、多種屬及大規(guī)格包裝定制。
B細(xì)胞種子庫高效篩選兔單抗
締碼生物擁有獨(dú)創(chuàng)的DIMA mAbs重組單克隆抗體開發(fā)平臺(tái)，可以在完成動(dòng)物免疫后直接從外周血中獲取陽性B細(xì)胞并克隆抗體基因序列。從單只免疫動(dòng)物中我們可以得到上萬個(gè)靶點(diǎn)結(jié)合陽性B細(xì)胞克隆，從中能夠更為高效的篩選出具有高特異性、高親和力重組單克隆抗體。
熱門抗體靶點(diǎn)
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
驗(yàn)證數(shù)據(jù)展示
A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.
Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.
Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10μg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10μg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)
A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.?
單克隆抗體
Monoclonal Antibodies
SKU: DMC100500 Target: HBEGF
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100497 Target: GPA33
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100494 Target: CD32a
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100493 Target: MUC1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100486 Target: CD23
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100484 Target: CDH1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100480 Target: DDR1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100477 Target: CCR6
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100476 Target: CD164
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100472 Target: EPHA4
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100686 Target: ALPP
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100673 Target: CRTAM
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100499 Target: CXCL1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100498 Target: GDNF
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100496 Target: LILRB2
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100495 Target: YAP1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100492 Target: GPR75
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100489 Target: CRTAM
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100487 Target: FZD10
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100483 Target: CHI3L1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100482 Target: C5AR2
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100481 Target: ADGRE1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100479 Target: APCDD1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100478 Target: GPR87
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100475 Target: SIGLEC7
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100474 Target: GDF15
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100473 Target: EMCN
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100467 Target: TGFBR2
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100465 Target: CCR1
Application: Flow Cyt; WB
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100463 Target: CD142
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100460 Target: FGFR4
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100471 Target: IL22
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
